This work involves the synthesis of new series of pyrazole analogue. Phenyl hydrazine was treated with ethyl chloroacetate to get compound 1 (3-methyl-1-phenyl pyrazole-5-one). The obtained product was further treated with ethyl chloro acetate in the presence of acetone and k2co3 to give compound 2 [ethyl 2-(5-methyl-3-oxo-2-phenyl phyrazolidine- 1- yl)acetate]. The obtained product further treated with Hydrazine to get compound 3 [ 2 (- 5- methyl-3-oxo-2- phenylpyrazolidin-1-yl) acetohydrazide ]. The product is further reacted with aryl aldehydes to get compound4(A-J).[(E)-N-substituted-2-(5-methyl-3-oxo-2-phenylpyrazolidin-1-yl) acetohydrazine]. The obtained compounds were characterized and confirmed by M.P, FTIR and 4E was confirmed by 1HNMR. Some selected synthesized compounds were screened for in-vitro anti- inflammatory activity. In this compound 3 found very significant activity. And also compared physico-chemical data and correlated the biological activity with standard drug Antipyrine and DART by using software: Molinspiration and Swiss ADME.