Parkinson’s Disease (PD) is one of the neurological conditions that progresses in the brain and is marked by rigidity, slowness of movement and loss of balance. The loss of brain tissue that results in cognitive and behavioral deficits is the hallmark of neurodegenerative disorders, which is a public health issue. Current conventional therapy can manage the symptoms of Parkinson’s Disease but they exhibit certain drawbacks of limited oral bioavailability and extensive hepatic metabolism. The development of innovative drug delivery methods for the encapsulating plant phytochemicals including inorganic, organic and hybrid nanoparticles, has made significant advances over the last few generations. In terms of stability, absorption, toxicity, bioavailability, pharmacology, distribution, prolonged release and both physical and chemical degradation, it is confirmed that new formulae outperform conventional and previously employed systems. To overcome these limitations novel therapies are utilized, which include nanotechnology, bee venom therapy and ultrasonic waves to stimulate dopamine release. Recent novel technology helps deliver the drug across BBB. The article summaries the Etiopathology and various current Novel drug delivery advancements utilized for the management of Parkinson’s disease along with the herbal medications. The history of herbal medicine dates back to early cultures. It encompasses the use of medicinal plants to treat illness and improve wellbeing in general.